Familial Hypercholesterolemia

A Site By Elijah Sommer, Muhlenberg College

Familial Hypercholesterolemia

What is Familial Hypercholesterolemia? Familial hypercholesterolemia is an inherited genetic disorder that predisposes afflicted individuals to early onset atherosclerotic heart disease. The disorder results from an inability of these persons to manage the levels of LDL-C (sometimes referred to as “bad cholesterol”) within their blood. It was originally identified by a Norwegian physician in the…
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Et tu, Squalene?

A model showing how downregulation of SQLE expression in ALK+ ALCLs renders the cells auxotrophic with respect to cholesterol. This act, in turn, causes squalene to accumulate within the cell. Squalene may serve as a buffer against lipid peroxidation of membrane PUFAs, thereby promoting cancer cell survival and averting ferroptotic cell death. Original Paper: Squalene…
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Reflection Blog 3: Structuring A Literature Review on Familial Hypercholesterolemia

After assembling a plethora of literature surrounding my disease of interest, Familial Hypercholesterolemia (FH), I have begun to think about the way in which I will structure my website-based literature review on this topic. The course of development of our current best understanding of FH, from its initial clinical identification as a genetic illness to…
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Diseases of Interest: A Reflection

The molecular basis of human pathology is as expansive as it is intriguing. Better characterization of disease in this capacity can translate to clinical insights, ultimately resulting in better outcomes for those who suffer from them. For my culminating undergraduate experience, I am interested in further investigating one of the following three diseases: Castration-Resistant Prostate…
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Why Study Biochemistry?

For the average college student, the term “biochemistry” is likely to elicit thoughts about the four major biomolecules or perhaps chemical processes like the fermentation of alcohol that occurs in yeast (i.e.”chemistry with things that can’t hurt you”). However, this is a superficial and fairly naive conception of what the science of biochemistry actually entails.…
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A Useful Adage

This is a practice post.

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